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Faculty of Nursing
University of Alberta

Hegadoren, Kathleen

Kathleen M. Hegadoren, RN PhD
Professor and Canada Research Chair in Stress-related Disorders in Women

Email: kathy.hegadoren@ualberta.ca
Website: http://www.nursing.ualberta.ca/whru/
Phone: (780) 492-4591
Fax: (780) 492-2551
Office: CSB 4-130G

Mailing address:
Faculty of Nursing
University of Alberta
3rd Floor Clinical Sciences Building
Edmonton, Alberta
T6G 2G3 Canada

Educational Background

  • Nursing Diploma, Royal Alexandra Hospital, Edmonton (1971)
  • Post-RN B.Sc. (Nursing) University of Alberta, Edmonton (1987)
  • M.Sc. in Psychiatry (Neurochemistry), Department of Psychiatry, University of Alberta (1990)
  • Ph.D. in Medical Sciences - Psychiatry, University of Alberta (1995)
  • Postdoctoral Fellowship - Department of Pharmacology, University of Alberta (1996)

Clinical and Teaching Areas

  • Clinical Nurse Specialist - child and adolescent psychiatry and adult psychiatry
  • Advanced Practice in Mental Health
  • Neurobiology and neuropsychopharmacology
  • Gender issues in psychiatry
  • Stress and Women's Health
  • Drug metabolism
  • Pharmacotherapeutics
  • Recreational drug use

Research

  • Women and stress disorders
  • Gender differences in psychiatric treatment response
  • Role of stress and stress hormones in etiology of depression
  • Childhood interpersonal trauma and adaptation
  • Posttraumatic stress syndromes
  • Risks involved in the recreational use of "Ecstasy' in humans. My doctoral thesis titled Metabolic, Behavioral and Neurochemical Studies of 3,4-Methylenedioxy Analogues of Amphetamine involved a multidimensional approach to characterize the popular recreational drugs "Ecstasy" and "Eve". Two recent reviews have been published regarding the risks.

Recent Publications and Abstracts (within the last 5 years)

Articles

  • Norris, C. M., Patterson, L., Galbraith, D., & Hegadoren, K. M. (2009). All you have to do is call; a pilot study to improve the outcomes of patients with coronary artery disease. Applied Nursing Research, 22(2), 133-137.
  • Norris, C. M., Hegadoren, K. M., Patterson, L., & Pilote, L. (2008). Sex differences in prodromal symptoms of patients with acute coronary syndrome: A pilot study. Progress in Cardiovascular Nursing, 23(1), 27-31.
  • Slater-MacLean, L., Cembrowski, G., Chin, D., Shalapay, C., Binette, T., Hegadoren, K., et al. (2008). Accuracy of glycemic measurements in the critically ill. Diabetes Technology and Therapeutics, 10(3), 169-177.
  • Woods, D. L., Kovach, C. R., Raff, H., Joosse, L., Basmadjian, A., & Hegadoren, K. M. (2008). Using saliva to measure endogenous cortisol in nursing home residents with advanced dementia. Research in Nursing and Health, 31(3), 283-294.
  • Lasiuk, G. C., & Hegadoren, K. M. (2007). The effects of estradiol on central serotonergic systems and its relationship to mood in women. Biological Research for Nursing, 9(2), 147-160.
  • Nicole, L., Duffett-Leger, L., Stewart, M., Hegadoren, K., Dennis, C. -., Rinaldi, C. M., et al. (2007). Canadian mothers' perceived support needs during postpartum depression. JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing, 36(5), 441-449.
  • Norris, C. M., Hegadoren, K., & Pilote, L. (2007). Depression symptoms have a greater impact on the 1-year health-related quality of life outcomes of women post-myocardial infarction compared to men. European Journal of Cardiovascular Nursing, 6(2), 92-98. 
  • King, S. L., & Hegadoren, K. M. (2006). An integrative science approach: Value added in stress research. Nursing and Health Sciences, 8(2), 114-119.
  • Coupland NJ, Oglivie CJ, Hegadoren KM, Seres, P, Hanstock CC, Allen P (2005) Decreased prefrontal myoinositol in major depressive disorder. Biological Psychiatry.
  • O'Donnell T, Hegadoren KM, Coupland (in press) Beta-endorphin: a review of its role in the pathophysiology of depression. Depression and Anxiety.
  • Lasiuk G, Hegadoren KM (in press) Posttraumatic Stress Disorder Part I: Historical Development of the Conceptual Framework. Perspectives in Psychiatric Nursing.
  • Lasiuk G, Hegadoren KM (in press) Posttraumatic Stress Disorder Part II: Development of the Diagnostic Construct within the North American Psychiatric Nosology. Perspectives in Psychiatric Nursing.
  • Hegadoren KM, Lasiuk G (in press) Posttraumatic Stress Disorder Part III: PTSD and Interpersonal Trauma in Women. Perspectives in Psychiatric Nursing.
  • O'Donnell T, Coupland N, Hegadoren KM (2004) Noradrenergic mechanisms in the pathophysiology of PTSD. Neuropsychobiology 50:273-283.
  • Preston S, Hegadoren KM, Mitchell E (2004) Glass contamination in parenterally administered medication: implications for nursing practice. J Advanced Nursing.
  • Hegadoren KM (2004) Assessment and treatment of depression: a review in high risk populations. J Wound, Ostomy Continence Nursing 31:100-112.
  • Carter-Snell C, Hegadoren KM (2003) Gender and stress-related disorders: implications for theory and research. Cdn J Nursing Research 35:34-55.
  • Coupland N, Hegadoren K (2003) Beclomethasone induced vasoconstriction in women with major depressive disorder. J Psychiatry & Neuroscience 28:364-369.
  • Coupland N, Hegadoren K, Myrholm J, (2003) Increased beclomethasone-induced vasoconstriction in women with posttraumatic stress disorder. J Psychiatric Research 37/3:221-228.
  • Struzik L, Duffin J, Hegadoren K, Vermani M, Katzman M (2002) Effects of tryptophan depletion on central and peripheral chemoreflexes in man. Respiratory Physiology & Neurobiology 133:183-195.
  • King S, Hegadoren KM (2002) Stress Hormones: How do they measure up? J Biol Nursing 4:92-103.

Grants

  • Intimate partner Violence as a model of chronic severe stress. CIHR Operating grant 10/05-09/08.
  • Integrated Prospective Studies in Traumatized Populations. CFI Innovation grant. Principal Investigator.
  • STRESS: Stress, Trauma, Recovery: Early Stage Studies. CIHR New Emerging Team Grant in PTSD. 06/03-06/08.
  • Prefrontal glutamate in major depressive disorder. CIHR operating grant 07/03 – 06/06.
  • CIHR Strategic Training Program in Maternal-Infant Health.. 07/03-06/06.
  • Fatigue in Ill and Non-ill Populations. Hole Family Fund. 02/03 – 02/04.
  • Use of HPLC and Spectrofluometry to investigate neuronal and neuroendocrine parameters in Neuropsychiatric disorders and gender differences in drug metabolism. Funded by CIHR Equipment Grant.

Special Achievements and Affiliations

Awards

  • Awarded Canada Foundation for Innovation funding to build laboratory facilities dedicated to studies in women's health/mental health (1998)
  • Clinical Nurse Researcher, Clarke Institute of Psychiatry, Toronto, Ontario (1996-1997)
  • Postdoctoral Fellowship, Canadian Psychiatric Research Foundation (1996).
  • Helen Hunley Graduate Scholarship for Studies in Mental Health, Alberta Heritage Foundation for Medical Research (1993-1995)
  • Medical Research Council of Canada Studentship (1991-1993)
  • W.H. Johns Graduate Fellowship, U of A (1991-1995)
  • CIHR New Emerging Team in PTSD (2002)

Affiliations

  • Member, Canadian College of Neuropsychopharmacology (since1990)
  • Member, Alberta Association of Registered Nurses (since 1971)
  • Member, The Center for Research in Women's Health, Toronto, Ontario
  • Member, Canadian Federation of Mental Health Nurses
  • Community Participant, "Changing Together" - a program for women escaping violence within relationships
  • Member, Perinatal Research Centre
  • Member, University Center for Neuroscience
  • Member, Neurochemical Research Unit