Stephen Moore
Professor - Agricultural, Food and Nutritional Science
Alberta Veterinary Research Institute
Degree: PhD, University of New South Wales
Room: 1415 College Plaza
Phone: (780) 492-0169
Fax: (780) 248-1900
Email: Stephen.Moore@ualberta.ca
Job/Research Area
Beef Cattle Genomics, and Member of AVRI Council
Major Responsibilities/Research Interests
The research program is aimed at identifying genes and gene pathways contributing towards quantitative traits in cattle. Research over the past decade has identified bovine chromosomal regions with loci affecting traits such as growth and morphology, yield, fat content and tenderness. Both structural (linkage and physical mapping) and functional genomics approaches are being developed to refine these results and identify the actual genes behind the quantitative traits. The results of the human and mouse genome efforts will be employed through high resolution synteny mapping utilising radiation hybrid panels and haplotype mapping, in order to identify candidate genes for specific traits. These candidates will be tested in industry herds. A second approach utilising expression mapping is being used to identify genes affecting economically important traits. This functional genomics approach will develop expression arrays from tissues such as adipose, muscle and gut as probes to study gene expression modulation in response to both genetic and environmental influences. Bioinformatics tools will be utilised to analyse large data sets arising from the large arrays containing tens of thousands of genes.
Graduate/PDF Career Opportunities
Selected Publications
Nkrumah, J.D., C. Li., J. Yu, C. Hansen, D.H. Keisler, and S.S. Moore. 2005. "Polymorphisms in the bovine leptin promotor associated with serum leptin concentration, growth, feed intake, feeding behavior and measures of carcass merit." J. Anim. Sci. 83: 20-28.
Schenkel, F.S., S.P. Miller, X. Ye, S.S. Moore, J.D. Nkrumah, C. Li, J. Yu, I.B. Mandell, J.W. Wilton, and J.L. Williams. 2005. "Association of single nucleotide polymorphisms in the leptin gene with carcass and meat quality traits of beef cattle." J. Anim. Sci. 83:2009-2020.
Valle, E., S.S. Moore, O. Jann, J.L. Williams, D.H. Crews, and B.F. Benkel. 2005. "The bovine cocaine and amphetamine-regulated transcript locus: gene characterization and SNP discovery." Animal Genetics 36(1):74-75.
Wang, Z., J.A. Basarab, L.A. Goonewardene, D.H. Crews Jr., P. Ramsey, K.L. Lyle, N. French, E.K. Okine, and S.S. Moore. 2005. "Test Duration for Residual Feed Intake in Commercial Bulls." Journal of Animal and Veterinary Advances (JAVA) 4(10).
Byrne, K., S. Johnson, W. Barendse, and S.S. Moore. 2002. "CSY234: a SINE-associated genetic and physical marker on bovine chromosome X." Animal Genetics 33:163-164.
Li, Y, J. Basarab, W. Snelling, B. Benkel, B. Murdoch, and S.S. Moore. 2002. "The distribution of haplotypes in bovine chromosome 5 within a commercial line of Bos Taurus and their associations with growth traits." J. Animal Sc. 80:1187-1194.
Li, Y., K. Byrne, E. Miggiano, V. Whan, S.S. Moore, S. Keys, P. Crocos, N. Preston, and S. Lehnert. 2002. "Genetic Mapping of the Juruma Prawn Penaeus japonicus Using AFLP Markers." Aquaculture, 219:143-156.
Wilson, K., Y. Li, V. Whan, S. Lrehnert, K. Byrne, S. Moore, S. Pongsomboon, A. Tasanakajon, G. Rosenberg, E. Ballmant, A. Fayazi, J. Swan, M. Kenway, and J. Benzie. 2002. "Genetic mapping of the black tiger shrimp Penaeus monodon with Amplifies Fragment Length Polymorphisms." Aquaculture 204:297-309.
Moore, S.S., V. Whan, G. Davis, K. Byrne, D.J.S. Hetzel, and N. Preston. 1999. "The development and application of genetic markers for the kuruma prawan Penaeus japonicus and their use in parentage determination and linkage mapping." Aquaculture 173:19-32.
Ellergren, H., S. Moore, N. Robinson, K. Byrne, W. Ward, and B.C. Sheldon. 1997. "Microsatellite evolution: a reciprocal study of repeat lengths at homologous loci in cattle and sheep." Mol. Biol. Evol. 14(8):854-860.
Hetzel, D.J.S. and S.S. Moore. 1995. "Applications of molecular genetic technologies in livestock improvement." In: Exploring approaches to research in the animal sciences in Vietnam: A workshop help in the city of Hue, Vietnam, 31 July-3 August 1995, W.J. Pryor, editor. ACIAR Proceedings No. 6.